Parkinson’s disease and Sleep.

May 12, 2009

There could be a connection between Parkinson’s disease and the sleep process.  The symptoms of Parkinson’s disease seem to have a similarity to the physical processes that occur when we are in a deep sleep.  When  we are asleep our gastrointestinal tract slows down. Our urinary system has dulled signals. Our need for swallowing decreases and the signals from our brains that tell our arms and legs what to do changes. Our need to have or control our facial impulses diminish. I think it is related in a basic way to Schizophrenia only because it occurs in the same area of the brain that is in control while we are asleep. Parkinson’s  symptoms occur due to a faulty disconnection from the sleep area of the brain just like a lamp that is only partially plugged into a wall getting flickering symptoms.

Schizophrenics have a disconnection difficulty with the mental aspects of sleep and Parkinson’s  effected people have a disconnection problem with the physical aspects of sleep.

More details can be read here:

https://axis1.wordpress.com/2007/08/15/rem-sleep-and-schizophrenia/

 

* What I think is interesting, is how Parkinsons symptoms seem to be the same as the physical

changes that happen to us during deep sleep.

ie..we dream we are running, but our legs don’t move.

And our gastrointestinal system slows down.

Our urinary system alters.

Our facial expressions while dreaming are flat.

 

And so Parkinsons and Schizophrenia both seem to me, to be

sleep disorders. Schizophrenia is a dream state while awake, and

Parkinsons is a physical sleep state while awake.


Older antipsychotic medication versus mordern antipsychotic medication and Dopamine re uptake versus Dopamine blocking.

March 27, 2008

Older anti-psychotics work very well for acutely and floridly psychotic people. Modern anti-psychotics seem to be objectively very poor in my opinion at treating acute psychosis. This could be due to the mechanisms of action.

If the process of psychosis involves the flooding of the brain with Dopamine, perhaps the excess Dopamine is being picked up by Dopamine receptors from dormant neighbouring, neuron dopamine receptors. The old fashioned anti-psychotics block re-uptake, therefore preventing the Dopamine from entering dormant neurons. Modern antipsychotics block the Dopamine to slow the flow of Dopamine into the synapse. If there is already a flooded overload of Dopamine, then there is little immediate benefit to be had from Modern Antipsychotics.

Modern anti psychotics probably have a better chance of achieving results in prodromal or mild/emerging psychosis or as a preventative measure in a schizophrenic who is experiencing a remission of symptoms.

Another take is that newer antipsychotics are just not sedating enough and so they don’t increase sleep or REM sleep.  Modern antipsychotics aren’t as sedating.